Annual report pursuant to Section 13 and 15(d)

Income Taxes (Details Textual)

v3.8.0.1
Income Taxes (Details Textual) - USD ($)
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
U.S. Federal statutory rate 34.00% 34.00% 34.00%
Deferred tax assets, valuation allowance $ 40,894,314 $ 47,802,380  
Decrease related to tax cuts and jobs act 17,900,000    
Orphan Drug Credits [Member]      
Net operating losses $ 5,000,000    
Net operating loss expiration date Dec. 31, 2027    
Domestic Tax Authority [Member]      
Net operating losses $ 123,300,000    
Net operating loss expiration date Dec. 31, 2018    
Domestic Tax Authority [Member] | Research Tax Credit Carryforward [Member]      
Net operating losses $ 1,300,000    
Net operating loss expiration date Dec. 31, 2033    
State and Local Jurisdiction [Member]      
Net operating losses $ 77,500,000    
Net operating loss expiration date Dec. 31, 2035