Income Taxes (Details) - USD ($)  | 
Dec. 31, 2017  | 
Dec. 31, 2016  | 
|---|---|---|
| Deferred tax assets: | ||
| Net operating losses carry forward | $ 30,826,534 | $ 38,874,255 | 
| Share-based compensation | 3,731,413 | 8,081,711 | 
| Research & Development/Orphan Drug Credits | 6,324,998 | 830,085 | 
| Others | 11,369 | 16,329 | 
| Less: valuation allowance | (40,894,314) | (47,802,380) | 
| Deferred tax assets, net | $ 0 | $ 0 | 
| X | ||||||||||
- References No definition available. 
  | 
| X | ||||||||||
- References No definition available. 
  | 
| X | ||||||||||
- Definition Amount after allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards. Reference 1: http://www.xbrl.org/2003/role/presentationRef 
  | 
| X | ||||||||||
- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible operating loss carryforwards. Reference 1: http://www.xbrl.org/2003/role/presentationRef 
  | 
| X | ||||||||||
- Definition Amount, before allocation of valuation allowance, of deferred tax asset attributable to deductible temporary differences, classified as other. Reference 1: http://www.xbrl.org/2003/role/presentationRef 
  | 
| X | ||||||||||
- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from share-based compensation. Reference 1: http://www.xbrl.org/2003/role/presentationRef 
  | 
| X | ||||||||||
- Definition Amount of deferred tax assets for which it is more likely than not that a tax benefit will not be realized. Reference 1: http://www.xbrl.org/2003/role/presentationRef 
  |