Annual report pursuant to Section 13 and 15(d)

Income Taxes (Details 1)

v3.8.0.1
Income Taxes (Details 1) - USD ($)
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Income Tax Disclosure [Abstract]      
Federal income taxes at 34% $ (9,044,420) $ (8,269,386) $ (7,148,607)
Federal income taxes at 34%, percentage (34.00%) (34.00%) (34.00%)
State income taxes $ (1,940,945) $ 973,547
State income taxes, percentage (7.30%) 4.00%
Change in Federal statutory rate $ 17,939,714    
Change in Federal statutory rate, percentage 67.40%    
Deferred true-up $ 3,090,815 $ (10,511,380) $ 1,104,763
Deferred true-up, percentage 11.80% (43.30%) 5.20%
Research and Development/Orphan Drug Tax Credit $ (3,029,074) $ (141,769)
Research and Development/Orphan Drug Tax Credit, percentage (11.40%) (0.60%)
Unrealized derivative gain/loss $ (120,870) $ (956,840)
Unrealized derivative gain/loss, percentage (0.50%) (3.90%)
Other $ 12,845 $ 13,632
Other, percentage 0.00% 0.10%
Change in valuation allowance $ (6,908,065) $ 18,892,196 $ 6,043,844
Change in valuation allowance, percentage (26.00%) 77.70% 28.80%
Provision for income tax
Provision for income tax, percentage