Annual report pursuant to Section 13 and 15(d)

Consolidated Statement of Changes in Stockholders' Equity (Deficit)

Consolidated Statement of Changes in Stockholders' Equity (Deficit) - USD ($)	Common Stock	Additional Paid-In Capital	Accumulated Deficit	Total
Beginning Balance at Dec. 31, 2014	$ 29,972	$ 89,252,262	$ (91,204,764)	$ (1,922,530)
Beginning Balance, Shares at Dec. 31, 2014	29,971,839
Stock-based compensation	$ 345	7,061,277		7,061,622
Stock-based compensation, Shares	344,784
Proceeds from the sale of common stock and warrants, net of offering costs	$ 11,994	37,625,965		37,637,959
Proceeds from the sale of common stock and warrants, net of offering costs, Shares	11,993,641
Issuance of common stock from exercise of options	$ 20	15,660		15,680
Issuance of common stock from exercise of options, Shares	20,000
Issuance of common stock from exercise of warrants	$ 1,736	156,204		157,940
Issuance of common stock from exercise of warrants, Shares	1,736,277
Transfer of warrant derivatives from liability to equity classification		48,691		48,691
Net loss			(21,025,314)	(21,025,314)
Ending Balance at Dec. 31, 2015	$ 44,067	134,160,059	(112,230,078)	21,974,048
Ending Balance, Shares at Dec. 31, 2015	44,066,541
Stock-based compensation	$ 82	4,297,696		4,297,778
Stock-based compensation, Shares	81,700
Proceeds from the sale of common stock and warrants, net of offering costs	$ 11,504	16,011,163		16,022,667
Proceeds from the sale of common stock and warrants, net of offering costs, Shares	11,504,427
Issuance of common stock from exercise of options	$ 23	18,082		18,105
Issuance of common stock from exercise of options, Shares	23,212
Issuance of common stock from exercise of warrants	$ 126	(126)
Issuance of common stock from exercise of warrants, Shares	125,862
Transfer of warrant derivatives from liability to equity classification		17,455		17,455
Net loss			(24,321,724)	(24,321,724)
Ending Balance at Dec. 31, 2016	$ 55,802	154,504,329	(136,551,802)	18,008,329
Ending Balance, Shares at Dec. 31, 2016	55,801,742
Stock-based compensation	$ 93	3,474,282		3,474,375
Stock-based compensation, Shares	93,385
Proceeds from the sale of common stock and warrants, net of offering costs	$ 24,173	18,765,461		18,789,634
Proceeds from the sale of common stock and warrants, net of offering costs, Shares	24,172,973
Issuance of common stock from exercise of warrants	$ 4	(4)
Issuance of common stock from exercise of warrants, Shares	4,234
Net loss			(26,601,235)	(26,601,235)
Ending Balance at Dec. 31, 2017	$ 80,072	$ 176,744,068	$ (163,153,037)	$ 13,671,103
Ending Balance, Shares at Dec. 31, 2017	80,072,334