Annual report pursuant to Section 13 and 15(d)

Equity (Details)

Equity (Details) - USD ($) $ / shares in Units, $ in Thousands		1 Months Ended		12 Months Ended
	Apr. 24, 2020	Aug. 31, 2020	Jun. 19, 2020	Dec. 31, 2021	Dec. 31, 2020	Nov. 09, 2021	Nov. 18, 2020	Jun. 30, 2020	Apr. 30, 2020	Dec. 31, 2019	Mar. 14, 2017	Dec. 31, 2013	Sep. 30, 2013
Equity (Details) [Line Items]
Sale of common stock, shares	4,300,000			4,600,000	2,100,000
Warrants to purchase shares of common stock	2,800,000
Public offering each share of common stock (in Dollars per share)	$ 4.5
Each pre-funded warrant (in Dollars per share)	4.497
Exercise price of warrant (in Dollars per share)	$ 0.003		$ 0.003		$ 0.003
Gross proceeds (in Dollars)	$ 31,600			$ 36,500	$ 22,600
Net proceeds of public offering (in Dollars)	$ 29,100
Issuance of common stock					700,000
Pre-funded amount					700,000
Equity description		the Company entered into the Capital on Demand™ Sales Agreement with JonesTrading Institutional Services LLC (“JonesTrading”), pursuant to which the Company may sell, from time to time, through or to JonesTrading, up to an aggregate of $200 million of its common stock. Shares of common stock are offered pursuant to the Company’s shelf registration statement on Form S-3 filed with the SEC on August 7, 2020.
Net proceeds (in Dollars)				$ 35,300	$ 21,700
Stock option				881,000	458,000
Option exercise price minimum (in Dollars per share)				$ 6.02	$ 6.63
Option exercise price maximum (in Dollars per share)				$ 9.25	$ 12.41
Stock options, term				10 years	10 years
Aggregated fair value (in Dollars)					$ 3,200
Stock option cancelations				333,000	23,000
Exercised for shares of common stock					1,000
Unrecognized compensation expense (in Dollars)					$ 4,900
Vesting period					3 years 3 months 18 days
Compensation expense related to stock options (in Dollars)				$ 1,500	$ 1,200
Outstanding warrant to purchase shares of common stock, issued											1,907
Deemed dividend to common stockholders (in Dollars)					1
Stock based compensation expense warrants (in Dollars)				$ 16	$ 13
2013 Amended and Restated Stock Plan [Member]
Equity (Details) [Line Items]
Number of shares authorized				758,333									91,666
Equity Option [Member]
Equity (Details) [Line Items]
Aggregate fair value (in Dollars)				$ 3,900
Minimum [Member] \| Equity Option [Member]
Equity (Details) [Line Items]
Vesting period				4 years	4 years
Maximum [Member] \| Equity Option [Member]
Equity (Details) [Line Items]
Vesting period				4 years 2 months 12 days	4 years 2 months 12 days
Warrant [Member]
Equity (Details) [Line Items]
Exercise price of warrant (in Dollars per share)								$ 15.62	$ 26.4
2019 Amended and Restated Stock Plan [Member]
Equity (Details) [Line Items]
Number of shares authorized						5,833,333	3,083,333			333,333
2013 Equity Incentive Plan [Member]
Equity (Details) [Line Items]
Number of shares authorized												33,333	15,000
Pre-Funded Warrants [Member]
Equity (Details) [Line Items]
Exercise price of warrant (in Dollars per share)					$ 0.003
Gross proceeds (in Dollars)			$ 25,000
Net proceeds of public offering (in Dollars)			$ 23,000
Issuance of common stock			1,900,000		2,800,000
Warrant to purchase of common stock			700,000
Exercise price per share (in Dollars per share)					$ 0.003
Common Stock [Member]
Equity (Details) [Line Items]
Share price (in Dollars per share)			$ 9.75
Warrant [Member]
Equity (Details) [Line Items]
Share price (in Dollars per share)			$ 9.747