Income Taxes (Details Textual) - USD ($) |
12 Months Ended | ||
|---|---|---|---|
Dec. 31, 2018 |
Dec. 31, 2017 |
Dec. 31, 2016 |
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| Net operating loss expiration date | Dec. 31, 2035 | ||
| U.S. Federal statutory rate | 21.00% | 34.00% | 34.00% |
| Deferred tax assets, valuation allowance | $ 46,394,528 | $ 40,894,314 | |
| Decrease related to tax cuts and jobs act | $ 17,900,000 | ||
| State income tax purposes, net operating losses | 144,500,000 | ||
| Federal income tax purposes, net operating losses | 66,800,000 | ||
| Research Tax Credit Carryforward [Member] | Domestic Tax Authority [Member] | |||
| Net operating losses | $ 1,400,000 | ||
| Net operating loss expiration date | Dec. 31, 2033 | ||
| Orphan Drug Credits [Member] | |||
| Net operating losses | $ 7,500,000 | ||
| Net operating loss expiration date | Dec. 31, 2037 | ||
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- Definition Amount of deferred tax assets for which it is more likely than not that a tax benefit will not be realized. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition Percentage of domestic federal statutory tax rate applicable to pretax income (loss). Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to increase (decrease) in foreign income tax contingency. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to increase (decrease) in state and local income tax contingency. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition Amount of operating loss carryforward, before tax effects, available to reduce future taxable income under enacted tax laws. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition Expiration date of each operating loss carryforward included in operating loss carryforward, in CCYY-MM-DD format. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition Amount of increase (decrease) in the valuation allowance for a specified deferred tax asset. Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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