Annual report pursuant to Section 13 and 15(d)

Income Taxes (Details 1)

v3.19.1
Income Taxes (Details 1) - USD ($)
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Income Tax Disclosure [Abstract]      
Federal statutory income taxes $ (4,967,332) $ (9,044,420) $ (8,269,386)
Federal statutory income taxes, percentage (21.00%) (34.00%) (34.00%)
State income taxes $ 1,413,678 $ (1,940,945) $ (973,547)
State income taxes, percentage 6.00% (7.30%) (4.00%)
Change in Federal statutory rate $ 17,939,714
Change in Federal statutory rate, percentage 67.40%
Deferred true-up $ 3,090,816 $ (10,511,380)
Deferred true-up, percentage 11.80% (43.30%)
Research and Development/Orphan Drug Tax Credit $ (1,986,609) $ (3,029,074) $ (141,769)
Research and Development/Orphan Drug Tax Credit, percentage (8.40%) (11.40%) (0.60%)
Unrealized derivative gain/loss $ (120,870) $ (956,840)
Unrealized derivative gain/loss, percentage (0.50%) (3.90%)
Other $ 40,049 $ 12,845 $ 13,632
Other, percentage 0.20% 0.00% 0.10%
Change in valuation allowance $ 5,500,214 $ (6,908,066) $ 18,892,196
Change in valuation allowance, percentage 23.20% (26.00%) 77.70%
Provision for income tax
Provision for income tax, percentage