On June 15, 2012, the Company entered into a license and sponsored research agreement with Fred Hutchinson Cancer Research Center (“FHCRC”) to build upon previous and ongoing clinical trials, with BC8 (licensed antibody). FHCRC has currently completed both a Phase 1 and Phase 2 clinical trial with BC8 and the Company initiated a pivotal Phase 3 trial leading to submission of a BLA. The Company has been granted exclusive rights to the BC8 antibody and related master cell bank developed by FHCRC. The cost to develop the trial will range from $25.0 million to $30.0 million, depending on the trial design as required by the FDA. Under the terms of the sponsored research agreement, the Company will fund the FHCRC lab with $0.2 million per year for the first two years and $0.3 million thereafter until June 2016. Payments made toward funding the lab will be credited toward royalty payments owed to FHCRC in the given year. A milestone payment of $1 million will be due to FHCRC upon FDA approval of the first drug. Upon commercial sale of the drug, royalty payments of 2% of net sales will be due to FHCRC.

 
For the nine months ended September 30, 2016 and 2015, the Company incurred expenses of approximately $0.4 million and $0.2 million, respectively, related to this agreement.

On February 27, 2014, the Company entered into a manufacturing agreement with Goodwin Biotechnology Inc. ("Goodwin"). Goodwin oversees the current Good Manufacturing Practices (cGMP) production of a monoclonal antibody anticipated to be used in an upcoming phase 3 clinical trial of Iomab-B. Total cost of the agreement is $5.7 million. The Company made a non-refundable payment of $0.6 million upon execution of the agreement. Periodic payments will be made upon reaching certain milestones. As of September 30, 2016, the remaining cost of the agreement is approximately $1.9 million. Goodwin bills the Company when services are rendered and the Company records the related expense to research and development costs.

For the nine months ended September 30, 2016 and 2015, the Company paid Goodwin approximately $0.5 million and $3.9 million, respectively. As of September 30, 2016 and December 31, 2015, the Company owed $0.1 million to Goodwin.

On September 30, 2014, the Company entered into a research agreement with the Albert Einstein College of Medicine of Yeshiva University (“Einstein”). According to the agreement, Einstein will use certain materials provided by the Company to complete a research project. The research project will explore the feasibility of using Actinium 225 to prepare patients with blood borne cancers to receive a hematopoietic stem cell transplant. Einstein will periodically provide the Company with reports showing project data or research. The total fixed price of the project is $0.2 million which is payable to Einstein in three payments.

During the nine months ended September 30, 2016 and 2015, the Company paid Einstein approximately $37,000 and $55,000, respectively  in full of the agreement.

On February 16, 2016, the Company entered into a CRO agreement with Medpace, Inc. (“Medpace”). Medpace provides project management services for the study of Iomab-B used for the intended Phase 3 clinical trial. The total project is estimated to cost approximately $7.2 million. The Company paid approximately $2.6 million during the nine months ended September 30, 2016. Medpace bills the Company when services are rendered and the Company records the related expense to research and development costs.

On August 4, 2016, the Company entered into a CRO agreement with Vector Oncology Solutions, LLC (“Vector”). Vector provides project management services for the study of Actimab-A used for the intended Phase 2 clinical trial. The total project is estimated to cost approximately $4.6 million. The Company paid approximately $0.7 million during the nine months ended September 30, 2016. Vector bills the Company when services are rendered and the Company records the related expense to research and development costs.