Annual report pursuant to Section 13 and 15(d)

Consolidated Statement of Changes in Stockholders' Equity Deficit

Consolidated Statement of Changes in Stockholders' Equity Deficit (USD $)	Total	Common Stock	Additional Paid-In Capital	Accumulated Deficit
Beginning Balance at Dec. 31, 2012	$ 1,145,635us-gaap_StockholdersEquity	$ 21,392	$ 56,867,706	$ (55,743,463)
Beginning Balance, Shares at Dec. 31, 2012		21,391,665
Stock-based compensation	657,812us-gaap_ShareBasedCompensation	265	657,547
Stock-based compensation, Shares		265,834
Proceeds from the sale of common stock	2,883,257	554	2,882,703
Proceeds from the sale of common stock, Shares		554,310
Issuance of common stock from exercise of options	13,053	17	13,036
Issuance of common stock from exercise of options, Shares		16,650
Issuance of common stock from exercise of warrants	3,467,395us-gaap_ProceedsFromWarrantExercises	2,337	3,465,058
Issuance of common stock from exercise of warrants, Shares		2,336,988
Transfer of warrant derivatives from liability to equity classification	1,047,095		1,047,095
Net loss	(10,773,792)us-gaap_NetIncomeLoss			(10,773,792)
Ending Balance at Dec. 31, 2013	(1,559,545)us-gaap_StockholdersEquity	24,565	64,933,145	(66,517,255)
Ending Balance, Shares at Dec. 31, 2013		24,565,447
Stock-based compensation	6,280,629us-gaap_ShareBasedCompensation	381	6,280,248
Stock-based compensation, Shares		379,901
Proceeds from the sale of common stock	15,435,305	2,380	15,432,925
Proceeds from the sale of common stock, Shares		2,379,433
Issuance of common stock from exercise of options	275,153	310	274,843
Issuance of common stock from exercise of options, Shares		310,400
Issuance of common stock from exercise of warrants	159,994us-gaap_ProceedsFromWarrantExercises	2,336	157,658
Issuance of common stock from exercise of warrants, Shares		2,336,658
Direct costs incurred before shares are issued	(30,000)		(30,000)
Transfer of warrant derivatives from liability to equity classification	2,203,443		2,203,443
Net loss	(24,687,509)us-gaap_NetIncomeLoss			(24,687,509)
Ending Balance at Dec. 31, 2014	$ (1,922,530)us-gaap_StockholdersEquity	$ 29,972	$ 89,252,262	$ (91,204,764)
Ending Balance, Shares at Dec. 31, 2014		29,971,839